4-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid → HCID 23146386, compound

HRID 598601Notes

Reaction equation

HRID 598601 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]([OH:16])=O)=[N:10][N:11]([CH3:13])[CH:12]=2)=[CH:4][CH:3]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[CH2:23][C:24]1[O:32][C:31]2[C:26](=[N:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:14]([N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]3[CH2:23][C:24]3[O:32][C:31]4[C:26](=[N:27][CH:28]=[CH:29][CH:30]=4)[CH:25]=3)=[O:16])=[N:10][N:11]([CH3:13])[CH:12]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 197686484-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acidHCID 23146382HCID 23146382, compound

Product 1

HCID 23146386HCID 23146386, compound

Procedure

The title compound was prepared using the method of Example 4, from 4-(4-fluoro-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid (110 mg, 0.5 mmol) and (RS)-2-Piperidin-2-ylmethyl-furo[3,2-b]pyridine, D47 (108 mg, 0.5 mmol), as a colourless solid (130 mg, 62%).

Sources & evidence

ORD record
ord-27f0a72ff6704aa7bb7af2ad23d9021d
Source dataset
uspto-grants-2011_03
Patent number
US07897618B2

Reaction notes

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