HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acid → 1-[(S)-2-(5,6-Difluoro-1H-benzoimidazol-2-ylmethyl)-pyrrolidin-1-yl]-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acid | HCID 23450138 | — |
| Reactant | 5,6-difluoro-2-(S)-1-pyrrolidin-2-ylmethyl-1H-benzoimidazole | HCID 66968223 | — |
| Product | 1-[(S)-2-(5,6-Difluoro-1H-benzoimidazol-2-ylmethyl)-pyrrolidin-1-yl]-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone | HCID 66968415 | — |
Reaction Steps
The title compound (65 mg) was prepared from 5,6-difluoro-2-(S)-1-pyrrolidin-2-ylmethyl-1H-benzoimidazole, D27 (153 mg) and 5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acid (205 mg) according to a procedure similar to that for Example 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897618B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-9c594c3547bd4361a5c13b12f40f12dd |
| Source note | uspto-grants-2011_03 |