Pyrazole → HCID 54767498, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of potassium carbonate (1.0 g, 7.24 mmol) and pyrazole (0.50 g, 7.35 mmol) in N,N-dimethylformamide (5 mL) was added 5-(3,5-dichlorophenyl)-3-(4-fluoro-3-methylphenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole (i.e. the product from Step B) (0.50 g, 1.27 mmol). The reaction mixture was stirred vigorously for 36 h at 120° C. Then the reaction mixture was absorbed onto silica gel, concentrated, and purified by flash chromatography on silica gel and eluted with a gradient of 0-25% ethyl acetate in hexane to afford the title product, a compound of the present invention, as a yellow oil (32.0 mg).

Provenance & Evidence