反应详情

温度

-78 °C

To a solution of 2-(4-methoxyphenyl)-2H-indazole (50 mg, 0.22 mmol) in methylene chloride (3 mL) at −78° C. was added boron tribromide (62 μL, 0.66 mmol). The reaction was stirred at −78° C. for 1 hour and room temperature for 1 hour. The reaction was quenched with saturated sodium bicarbonate solution. After the aqueous layer was extracted with methylene chloride, the combined organic layers were dried (MgSO4) and concentrated to give 28.4 mg of the desired indazole. LC-MS (C13H10N2O calculated 210) m/z 211 (M+H).

1. customThe reaction was quenched with saturated sodium bicarbonate solution
2. extractionAfter the aqueous layer was extracted with methylene chloride
3. dry with materialthe combined organic layers were dried (MgSO4)
4. concentrationconcentrated