HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598788Generated: October 30, 2026
2-Bromobenzaldehyde → HCID 11218363, compound
https://huagongshe.com/reaction/598788
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromobenzaldehyde | HCID 81129 | — |
| Reactant | 4-Methoxyphenylhydrazine hydrochloride | HCID 2723904 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 11218363 | HCID 11218363 | — |
Reaction Steps
2-Bromobenzaldehyde (74 mg, 0.4 mmol), 4-methoxyphenylhydrazine hydrochloride (70 mg, 0.4 mmol), sodium tert-butoxide (115 mg, 1.2 mmol), palladium(II) acetate (18 mg, 0.08 mmol) and 1,1′-bis(diphenylphosphino)ferrocene (44 mg, 0.08 mmol) were dissolved in toluene (0.6 mL) and heated to 100° C. overnight. The mixture was filtered through Celite with ethyl acetate, and the filtrate was concentrated. SiO2 chromatography (5-20% ethyl acetate/hexanes) gave the desired product, 30 mg. LC-MS (C14H12N2O calculated 224) m/z 225 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07897634B2 |
|---|
| Source dataset | uspto-grants-2011_03 |
|---|
| ORD ID | ord-8999b0a565294e1abadee7053f2803fb |
|---|
| Source note | uspto-grants-2011_03 |
|---|
