Boron trifluoride etherate → HCID 91042603, compound

Participants

Reaction Steps

To the bicyclic ether (228 mg, 1.065 mmol) and Et3SiH (370 mg, 3.196 mmol) in CH2Cl2 (5 mL) at room temperature, was added BF3.OEt2 (450 mg, 3.196 mmol) following the same reaction conditions as described in the synthesis of compound 3 to obtain compound 5 (140 mg, 58% three steps) as an oil. 1H NMR (CDCl3, 200 MHz): δ 5 (m, 1H), 4.5 (m, 1H), 3.95 (m, 1H), 3.74 (m, 1H), 2.7 (m, 1H), 2.1 (m, 3H), 2 (s, 3H), 1.5-1.9 (m, 3H).

Provenance & Evidence