反应详情

To a solution of tert-butyl(S)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-phenylbut-3-yn-2-ylcarbamate (0.089 g, 0.20 mmol) in 10 mL of MeOH was added 10% palladium on carbon (0.089 g). Hydrogen was bubbled through the reaction mixture for 5 minutes. The reaction was kept under a balloon atmosphere of hydrogen for 2 hours. The reaction mixture was then filtered through Celite and concentrated under reduced pressure. The obtained tert-butyl(R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-phenylbutan-2-ylcarbamate was used without any purification.

1. customHydrogen was bubbled through the reaction mixture for 5 minutes
2. filtrationThe reaction mixture was then filtered through Celite
3. concentrationconcentrated under reduced pressure
4. customThe obtained tert-butyl(R)-4-(3-(isoquinolin-6-yl)isoxazol-5-yl)-1-phenylbutan-2-ylcarbamate was used without any purification