Benzenepropanenitrile → N-((S)-2-Amino-3-(1H-indol-3-yl)propyl)-4-benzyl-3-(isoquinolin-6-yl)isoxazol-5-amine

Participants

Reaction Steps

This compound was synthesized in an analogous manner to Example 32 but using 3-phenylpropionitrile (commercially available from Acros Organics Order Number 17399) instead of acetonitrile in the preparation of allyl 4-benzyl-3-(isoquinolin-6-yl)isoxazol-5-ylcarbamate according to Scheme 6 instead of allyl 3-(isoquinolin-6-yl)isoxazol-5-ylcarbamate. MS m/z: 474 (M+1); 1H NMR (400 MHz, CD3OD) δ ppm 9.24 (s, 1H), 8.44 (d, J=5.87 Hz, 1H), 8.11 (d, J=8.61 Hz, 1H), 7.93 (s, 1H), 7.75 (dd, J=8.61, 1.37 Hz, 1H), 7.70 (d, J=5.87 Hz, 1H), 7.55 (d, J=7.82 Hz, 1H), 7.39 (d, J=8.02 Hz, 1H), 7.04-7.24 (m, 8H), 3.82 (m, 3H), 3.60-3.73 (m, 2H), 3.21-3.25 (m, 1H), 3.13 (m, 1H).

Provenance & Evidence