HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-bromo-1H-indazole → HCID 57950500, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-bromo-1H-indazole | HCID 761929 | — |
| Reactant | (3S)-3-Amino-4-[4-(trifluoromethyl)phenyl]butanoic acid--hydrogen chloride (1/1) | HCID 2761665 | — |
| Reactant | 5-ethynyl-1H-indazole | HCID 17842433 | — |
| Reactant | HCID 178435597 | HCID 178435597 | — |
| Product | HCID 57950500 | HCID 57950500 | — |
Reaction Steps
As shown in Scheme 12, Example 37 was synthesized starting with commercially available (S)-3-amino-4-(4-(trifluoromethyl)phenyl)butanoic acid hydrochloride [PepTech Corporation, 20 Mall Road, Suite 460, Burlington, Mass. 01803, USA) and 5-bromo-1H-indazole [Fisher Scientific, 2000 Park Lane Drive, Pittsburgh, Pa. 15275, USA]. The 2 step synthesis of 5-ethynyl-1H-indazole was performed in a similar manner as the 5-ethynyl-3-methyl-1H-indazole required for Example 38, using 5-bromo-1H-indazole instead of 5-bromo-3-methyl-1H-indazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897619B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-48040d7c84cd42dda77c7bf366793a80 |
| Source note | uspto-grants-2011_03 |