5-bromo-1H-indazole → HCID 57950621, compound

Participants

Reaction Steps

Example 39 was synthesized in a similar fashion as Example 37 as shown in Scheme 12 starting with commercially available (S)-3-(tert-butoxycarbonyl)-4-phenylbutanoic acid (commercially available from PepTech Corporation) instead of (S)-3-amino-4-(4-(trifluoromethyl)phenyl)butanoic acid hydrochloride, and 5-bromo-1H-indazole. The synthesis of the required (S)-tert-butyl 4-azido-1-phenylbutan-2-ylcarbamate was performed in a similar manner as described for the (S)-tert-butyl 4-azido-1-(4-(trifluoromethyl)phenyl)butan-2-ylcarbamate (Examples 37 and 38) including one additional BOC deprotection step.

Provenance & Evidence