反应详情

(R)-tert-Butyl 3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-1-(4-(trifluoromethyl)phenyl)propan-2-ylcarbamate (10.0 g, 22.5 mmol) in 100 mL toluene was heated at 105° C. for 3 hours. Hexane was added, and the mixture was sonicated. The resulting solid was filtered. The desired product was obtained as a white amorphous solid (21.0 g, yield 98%). No further purification was performed and the reaction was carried on to the next step.

1. customthe mixture was sonicated
2. filtrationThe resulting solid was filtered