2-Aminothiazole → N-[2-(3,4-Dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	3,4-Dimethoxyphenol	HCID 16251	—
Reactant	1-Fluoro-2-nitrobenzene	HCID 73895	—
Reactant	2-(3,4-Dimethoxyphenoxy)benzenamine	HCID 49766595	—
Product	1,2-Dimethoxy-4-(2-nitrophenoxy)benzene	HCID 11369382	68%
Product	N-[2-(3,4-Dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea	HCID 59732827	69%

Reaction Steps

2-(3,4-Dimethoxyphenoxy)-1-nitrobenzene (0.93 g, 68%) was prepared from 3,4-dimethoxyphenol (0.85 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(3,4-dimethoxyphenoxy)aniline (0.51 g, 62%) following general procedure B. N-[2-(3,4-Dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (128 mg, 69%) was prepared from 2-(3,4-dimethoxyphenoxy)aniline (123 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07897628B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-3c57514066ec459d909debf0d2584250
Source note	uspto-grants-2011_03