HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → N-[4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| Reactant | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| Reactant | 4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline | HCID 66998878 | — |
| Product | N-[4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732919 | 65% |
| Product | 4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene | HCID 66998789 | 65% |
Reaction Steps
4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.91 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 2,4-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure F. This compound was reduced to 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.61 g, 75%) following the general procedure C. N-[4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (122 mg, 65%) was prepared from 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897628B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-4ee5340b16ec4a9b9168996c0e679c04 |
| Source note | uspto-grants-2011_03 |