2-Aminothiazole → 2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	1-Fluoro-2-nitrobenzene	HCID 73895	—
Reactant	2,4-Difluorobenzene-1-thiol	HCID 2737073	—
Reactant	2-(2,4-Difluorophenylsulfanyl)aniline	HCID 43345446	—
Product	2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene	HCID 52479353	78%
Product	1-[2-(2,4-Difluorophenylsulfanyl)phenyl]-3-(thiazol-2-yl)urea	HCID 59732885	72%

Reaction Steps

2-(2,4-Difluorophenylsulfanyl)-1-nitrobenzene (1.04 g, 78%) was prepared from 2,4-difluorothiophenol (0.73 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,4-difluorophenylsulfanyl)-aniline (0.64 g, 70%) following the general procedure B. 1-[2-(2,4-Difluorophenylsulfanyl)-phenyl]-3-(thiazol-2-yl)urea (130 g, 72%) was prepared from 2-(2,4-difluorophenylsulfanyl)-aniline (118 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07897628B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-4df6a88b0dbb4fba869cd33075da49b9
Source note	uspto-grants-2011_03