反应详情

To a solution of 4-chloromethyl-thiazol-2-ylamine (7.45 g, 50.0 mmol) in dioxane:water mixture (8:2) was added sodium azide (4.87 g, 75.0 mmol) and the reaction mixture was refluxed for 2-3 h. The mixture was concentrated in vacuo to remove all dioxane and the residue was dissolved in EtOAc (200 mL). The organic layer was washed with water (2×200 mL), brine (2×200 mL), dried over (Na2SO4) and concentrated in vacuo to give 4-azidomethyl-thiazol-2-ylamine in 70-90% yield.

1. temperaturethe reaction mixture was refluxed for 2-3 h
2. concentrationThe mixture was concentrated in vacuo
3. customto remove all dioxane
4. dissolutionthe residue was dissolved in EtOAc (200 mL)
5. washThe organic layer was washed with water (2×200 mL), brine (2×200 mL)
6. dry with materialdried over (Na2SO4)
7. concentrationconcentrated in vacuo