HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → 2-Butoxy-4-methyl-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 2-Butoxy-4-methylbenzenamine | HCID 24708940 | — |
| Product | 2-Butoxy-4-methyl-1-nitrobenzene | HCID 18474285 | 75% |
| Product | HCID 59732836 | HCID 59732836 | 70% |
Reaction Steps
3-(1-Butoxy)-4-nitrotoluene (0.78 g, 75%) was prepared from 1-butanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(1-butoxy)aniline (0.47 g, 70%) following general procedure C. 1-(2-Butoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (210 mg, 70%) was prepared from 4-methyl-2-(1-butoxy)aniline (179 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897628B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-fd16b9fafd4c4ea1bb4d1dac71187ec7 |
| Source note | uspto-grants-2011_03 |