HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 3-(3-Methyl-but-2-enyloxy)-4-nitrotoluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 3-Methyl-2-buten-1-OL | HCID 11173 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-(3-methyl-but-2-enyloxy)aniline | HCID 66998473 | — |
| Product | 1-[4-Methyl-2-(3-methyl-but-2-enyloxy)-phenyl]-3-thiazol-2-yl-urea | HCID 59733134 | 65% |
| Product | 3-(3-Methyl-but-2-enyloxy)-4-nitrotoluene | HCID 66999096 | 72% |
Reaction Steps
3-(3-methyl-but-2-enyloxy)-4-nitrotoluene (0.8 g, 72%) was prepared from 3-methylbut-2-en-1-ol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(3-methyl-but-2-enyloxy)aniline (0.43 g, 62%) following general procedure B. 1-[4-Methyl-2-(3-methyl-but-2-enyloxy)-phenyl]-3-thiazol-2-yl-urea (206 mg, 65%) was prepared from 4-methyl-2-(3-methyl-but-2-enyloxy)aniline (191 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897628B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-4a2f6a7753d04ad8bd652a7608b29b8f |
| Source note | uspto-grants-2011_03 |