HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(Cyclopropylmethoxy)-4-methyl-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 2-(Cyclopropylmethoxy)-4-methylaniline | HCID 43560040 | — |
| Product | HCID 59732787 | HCID 59732787 | 72% |
| Product | 2-(Cyclopropylmethoxy)-4-methyl-1-nitrobenzene | HCID 66998873 | 75% |
Reaction Steps
3-Cyclopropylmethoxy-4-nitrotoluene (0.77 g, 75%) was prepared from cyclopropylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 2-cyclopropylmethoxy-4-methyl-aniline (0.47 g, 71%) following general procedure C. 1-(2-Cyclopropylmethoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (218 mg, 72%) was prepared from 2-cyclopropylmethoxy-4-methyl-aniline (177 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897628B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-e97e2e085d404c8297588ab50678b81b |
| Source note | uspto-grants-2011_03 |