化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → HCID 59732812、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Tetrahydropyran-2-methanol | HCID 7524 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | 4-Methyl-2-(tetrahydro-2H-pyran-2-ylmethoxy)-phenylamine | HCID 43591698 | — |
| 生成物 | HCID 59732812 | HCID 59732812 | 71% |
| 生成物 | Tetrahydro-2-[(5-methyl-2-nitrophenoxy)methyl]-2H-pyran | HCID 66999100 | 64% |
反応手順
4-Nitro-3-(tetrahydro-pyran-2-ylmethoxy)-toluene (0.80 g, 64%) was prepared from tetrahydropyran-2-ylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (0.50 g, 71%) following general procedure C. 1-[4-Methyl-2-(tetrahydro-pyran-2-ylmethoxy)-phenyl]-3-thiazol-2-yl-urea (246 mg, 71%) was prepared from 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (221 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-9b29828c03804d09a9bcfac8357df06f |
| 出典メモ | uspto-grants-2011_03 |