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2-Aminothiazole → 2-Fluoro-5-(2-methylpropoxy)-4-nitrotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Isobutanol | HCID 6560 | — |
| 反応物 | 1,4-Difluoro-2-methyl-5-nitrobenzene | HCID 230658 | — |
| 反応物 | 5-Fluoro-4-methyl-2-(2-methylpropoxy)aniline | HCID 45091606 | — |
| 生成物 | 1-(5-Fluoro-2-isobutoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732736 | 64% |
| 生成物 | 2-Fluoro-5-(2-methylpropoxy)-4-nitrotoluene | HCID 66999163 | 65% |
反応手順
2-Fluoro-5-(2-methylpropoxy)-4-nitrotoluene (0.73 g, 65%) was prepared from 2-methylpropanol (0.46 ml, 5.0 mmol) and 2,5-difluoro-4-nitrotoluene (0.86 g, 5.0 mmol) following the general procedure G. This was reduced to 5-fluoro-4-methyl-2-(2-methylpropoxy)-aniline (0.45 g, 70%) following general procedure C. 1-(5-Fluoro-2-isobutoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (205 mg, 64%) was prepared from 5-fluoro-4-methyl-2-(2-methylpropoxy)-aniline (197 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-199350ab23ab466a9131b26ae75568a8 |
| 出典メモ | uspto-grants-2011_03 |