Cesium carbonate → 4-Benzyl-3-{2-[5-(3,5-difluoro-benzyloxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoyl}-oxazolidin-2-one

Participants

Reaction Steps

To a solution of 4-benzyl-3-[2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoyl]-oxazolidin-2-one (18.77 g, 36.73 mmol) in acetonitrile (184 mL) at 0° C. was added 1-bromomethyl-3,5-difluoro-benzene (7.13 mL, 55.10 mmol) and Cs2CO3 (23.94 g, 73.46 mmol) in portions over 5 minutes. The resulting white suspension was stirred at room temperature for 2 h. The white solid was filtered off and the solvent was removed in vacuo to obtain relatively pure 4-benzyl-3-{2-[5-(3,5-difluoro-benzyloxy)-4′-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoyl}-oxazolidin-2-one.

Provenance & Evidence