Cesium carbonate → 4-Benzyl-3-{2-[5-(3,5-difluoro-benzyloxy)-4'-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoyl}-oxazolidin-2-one

Participants

Reaction Steps

To a solution of 4-benzyl-3-[2-(5-hydroxy-4′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoyl]-oxazolidin-2-one (0.400 g, 0.78 mmol) in acetonitrile (3 mL) at room temperature was added 1-bromomethyl-3,5-difluoro-benzene (0.243 g, 1.17 mmol) and Cs2CO3 (0.508 g, 1.56 mmol). The resulting white suspension was stirred for 1 h. The white solid was filtered off and the solvent was removed in vacuo to obtain relatively pure 4-benzyl-3-{2-[5-(3,5-difluoro-benzyloxy)-4′-trifluoromethyl-biphenyl-3-yl]-4-methyl-pentanoyl}-oxazolidin-2-one.

Provenance & Evidence