Aniline → Bis-(6-bromo-hexyl)-phenyl-amine

Temperature

97.5 °C

0.45 ml of aniline (5 mmol), 2.5 ml of dibromohexane (14.6 mmol), and sodium acetate (14.5 mmol) were charged in a reaction container and slowly heated to about 95 to 100° C. while generating bubbles under a nitrogen atmosphere. The reactant mixture was agitated for about 10 hours at about 95 to 100° C. The mixture was cooled down to room temperature, mixed with 30 ml of distilled water, and agitated for 10 minutes. The mixture was then treated to extract organic layers using ethylacetate, and then was distillated through reduced pressure distillation, thereby obtaining a sticky liquid. The sticky liquid was separated using preparative TLC (eluent: CH2Cl2:Hexane=1:2.5). The obtained compound was confirmed to be the compounds 221 of FIG. 3 using a 1H-NMR spectometry and mass spectometry. The results are shown in FIG. 5.

1. temperatureThe mixture was cooled down to room temperature
2. stirringagitated for 10 minutes
3. additionThe mixture was then treated
4. extractionto extract organic layers
5. distillationwas distillated through reduced pressure distillation
6. customobtaining a sticky liquid
7. customThe sticky liquid was separated

ORD record

ord-5d7d5fa79147443780191fa2d7ccd7fe

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07897735B2