4-(2-Chloroethyl)morpholine → HCID 10458706, compound

Participants

Reaction Steps

By treatment of 3-bromo-N-{5-[2-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-propionamide with 2-morpholin-4-yl-ethylamine (or 3-amino-N-{5-[2-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-propionamide with 4-(2-chloro-ethyl)-morpholine. Anal. RP-HPLC: tR=11.5 min (10-70% MeCN, purity >97%). 1H-NMR (DMSO-D6) δ: 1.52 (d, 2H, J=7.0 Hz, CH2), 2.48 (m, 2H, CH2), 2.52 (s, 3H, CH3), 3.05-3.11 (m, 4H, CH2), 3.25-3.28 (m, 6H, CH2), 4.08 (m, 2H, CH2), 7.13 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 7.29 (m, 2H, Ph-H), 7.82 (m, 2H, Ph-H), 8.51 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 9.82 (brs, 1H, NH).

Provenance & Evidence