3-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone → HCID 11724775, compound

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Reaction Steps

By condensation between 3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone and N-(4-acetamidophenyl)-guanidine nitrate. Pale solid. Mp. 219-220° C. 1H-NMR (DMSO-D6) δ: 2.00 (s, 3H, CH3), 2.61 (s, 3H, CH3), 2.64 (s, 3H, CH3), 7.04 (d, 1H, J=4.9 Hz, pyrimidinyl-H), 7.48 (d, 2H, J=8.8 Hz, Ph-H), 7.64 (d, 2H, J=8.8 Hz, Ph-H), 8.47 (d, 1H, J=5.4 Hz, pyrindinyl-H), 9.58 (s, 1H, NH), 9.82 (s, 1H, NH). MS (ESI+) m/z 340.02 [M+H]+ (C17H17N5OS requires 339.42).

Provenance & Evidence