HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone → [4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-methanesulfonyl-phenyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone | HCID 91621644 | — |
| Reactant | HCID 178504802 | HCID 178504802 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-methanesulfonyl-phenyl)-amine | HCID 10383920 | — |
Reaction Steps
By condensation of 3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone and N-(4-methanesulfonyl-phenyl)-guanidine nitrate. Yellow solid. Anal. RP-HPLC: tR=16.6 min (0-60% MeCN, purity >97%). 1H-NMR (DMSO-d6) δ: 2.65 (s, 3H, CH3), 2.66 (s, 3H, CH3), 3.15 (s, 3H, CH3), 7.22 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 7.84 (d, 2H, J=9.0 Hz, Ph-H), 8.03 (d, 2H, J=9.0 Hz, Ph-H), 8.61 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 10.23 (sbr, 1H, NH). MS (ESI+) m/z 361.17 [M+H]+ (C16H16N4O2S2 requires 361.46).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897605B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-b54cceb6c6254611abdea93ea433154b |
| Source note | uspto-grants-2011_03 |