HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 3,4-Dimethyl-5-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-3H-thiazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 5-(3-dimethylamino-acryloyl)-3,4-dimethyl-3H-thiazol-2-one | HCID 67269373 | — |
| Reactant | HCID 178480749 | HCID 178480749 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 3,4-Dimethyl-5-{2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-3H-thiazol-2-one | HCID 11383912 | — |
Reaction Steps
This compound was prepared by condensation between 5-(3-dimethylamino-acryloyl)-3,4-dimethyl-3H-thiazol-2-one and N-[4-(4-methyl-piperazin-1-yl)-phenyl]-guanidine nitrate. Pale solid. Anal. RP-HPLC: tR=10.9 min (0-60% MeCN in 0.1% aq CF3COOH over 20 min, 1 mL/min, purity >97%). 1H-NMR (CDCl3) δ: 2.42 (m, 4H, CH2), 2.53 (s, 3H, CH3), 3.04 (m, 4H, CH2), 3.28 (s, 3H, CH3), 6.84 (d, 1H, J=5.5 Hz, pyrimidinyl-H), 6.86 (d, 2H, J=9.0 Hz, Ph-H), 7.54 (d, 2H, J=9.0 Hz, Ph-H), 8.35 (d, 1H, J=5.5 Hz, pyrimidinyl-H), and 9.33 (s, 1H, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897605B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-7a09ce8b925b4732a3ac1e386325940b |
| Source note | uspto-grants-2011_03 |