1-Naphthyl Isothiocyanate → 1-Naphthalen-1-yl-3-[5-(3-nitro-phenoxy)-pentyl]-thiourea

Participants

Reaction Steps

To a solution of 5-(3-nitro-phenoxy)-pentylamine (867 mg, 3.87 mmol) in dichloromethane (5 mL) was added 1-naphthyl isothiocyanate (788 mg, 4.26 mmol) at room temperature. The reaction mixture was stirred at room temperature overnight. After removal of the solvent, the residue was purified by silica gel column chromatography to give 1-naphthalen-1-yl-3-[5-(3-nitro-phenoxy) -pentyl]-thiourea (1.3 g, 3.18 mmol, 82%) as a yellow gel.

Provenance & Evidence