Ammonia → HCID 178432226, compound

Participants

Reaction Steps

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 2-methyl-1H-benzimidazole-5-carboxylic acid (Acros) according to methods A and C; yield 83 mg, 0.21 mmol (58%): 1H NMR (300 MHz, methanol-d4) δ 2.02-2.31 (m, 5H), 2.50 (s, 2H), 2.89 (s, 3H), 3.50 (d, J=13 Hz, 2H), 3.57 (s, 2H), 3.92 (d, J=13 Hz, 2H), 4.32 (s, 1H), 7.82 (d, J=9 Hz, 1H), 8.11 (dd, J=9, 2 Hz, 1H), 8.33 (s, 1H), 8.57 (d, J=5 Hz, 1H); MS (DCI/NH3) m/z 311 (M+H)+; Anal. C18H22N4O2HCl1.0H2O: C, H, N.

Provenance & Evidence