Ammonia → HCID 178432226, compound

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2-methyl-1H-benzimidazole-5-carboxylic acid	HCID 1132609	—
Reactant	1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride	HCID 67152122	—
Product	HCID 178432226	HCID 178432226	—

Reaction Steps

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 2-methyl-1H-benzimidazole-5-carboxylic acid (Acros) according to methods A and C; yield 84 mg, 0.21 mmol (58%): 1H NMR (300 MHz, methanol-d4) δ 1.99 (d, J=13 Hz, 2H), 2.30-2.46 (m, 3H), 2.51 (s, 2H), 2.90 (s, 3H), 3.59 (s, 2H), 3.69 (s, 4H), 4.45 (s, 1H), 7.82 (dd, J=9, 1 Hz, 1H), 8.07 (dd, J=8, 1 Hz, 1H), 8.25 (dd, J=1, 1 Hz, 1H), 8.50 (d, J=5 Hz, 1H); MS (DCI/NH3) m/z 311 (M+H)+; Anal. C18H22N4O2HCl 1.0H2O: C, H,N.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07897766B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-f9fa3c425ba64f93a37a4d577a68dbc4
Source note	uspto-grants-2011_03