Ammonia → HCID 67152119, compound

HRID 599209Notes

Reaction equation

HRID 599209 reaction equation
Cl.[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[Cl:13][C:14]1[S:18][C:17]([C:19](O)=[O:20])=[CH:16][CH:15]=1.N>>[ClH:13].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH:12][C:19]([C:17]3[S:18][C:14]([Cl:13])=[CH:15][CH:16]=3)=[O:20])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 950485-Chloro-2-thiophenecarboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152119HCID 67152119, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-chlorothiophene-2-carboxylic acid (Aldrich) according to methods A and C; yield 56 mg, 0.17 mmol (53%): 1H NMR (300 MHz, methanol-d4) δ 1.95 (d, J=14 Hz, 2H), 2.17 (s, 1H), 2.29 (d, J=14 Hz, 2H), 2.43 (s, 2H), 3.55 (s, 2H), 3.64 (d, J=2 Hz, 4H), 4.34 (s, 1H), 7.04 (d, J=4 Hz, 1H), 7.69 (d, J=4 Hz, 1H); MS (DCI/NH3) m/z 297, 299 (M+H)+; Anal. C14H17ClN2OS.HCl 0.1H2O: C, H, N.

Sources & evidence

ORD record
ord-6460bd29d446410ba3f3a54d6c204850
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

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