HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Phenylthiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Phenylthiophene-2-carboxylic acid | HCID 1223184 | — |
| Reactant | 1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride | HCID 67152122 | — |
| Product | 4-Phenylthiophene-2-carboxylic acid (4r)-(1-azatricyclo[3.3.1.13,7]dec-4-yl)-amide hydrochloride | HCID 67152143 | — |
Reaction Steps
Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 4-phenylthiophene-2-carboxylic acid (Oakwood) according to methods A and C; yield 54 mg, 0.14 mmol (44%): 1H NMR (300 MHz, DMSO-d6) δ 1.86-1.98 (m, 2H), 2.06 (d, J=13 Hz, 3H), 2.24 (s, 2H), 3.35 (d, J=9 Hz, 4H), 3.84 (d, J=13 Hz, 2H), 4.10-4.20 (m, 1H), 7.26-7.36 (m, 1H), 7.43 (t, J=7 Hz, 2H), 7.69-7.78 (m, 2H), 8.08 (d, J=1 Hz, 1H), 8.45 (d, J=6 Hz, 1H), 8.54 (d, J=1 Hz, 1H); MS (DCI/NH3) m/z 339 (M+H)+; Anal. C20H22N2OS.HCl 0.07H2O: C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897766B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-3a41e32af03245e88e8693117066481d |
| Source note | uspto-grants-2011_03 |