Ammonia → HCID 67152140, compound

HRID 599214Notes

Reaction equation

HRID 599214 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[N:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]1[S:23][C:22]([C:24](O)=[O:25])=[CH:21][CH:20]=1.N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:24]([C:22]3[S:23][C:19]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][N:13]=4)=[CH:20][CH:21]=3)=[O:25])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 7364825-(Pyridin-2-yl)thiophene-2-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152140HCID 67152140, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-(2-pyridyl)thiophene-2-carboxylic acid (Maybridge) according to methods A and C; yield 35 mg, 0.09 mmol (43%): 1H NMR (300 MHz, methanol-d4) δ 2.07-2.29 (m, 5H), 2.48 (s, 2H), 3.49 (d, J=12 Hz, 2H), 3.56 (s, 2H), 3.83 (d, J=13 Hz, 2H), 4.26 (s, 1H), 7.29-7.39 (m, 1H), 7.71 (d, J=4 Hz, 1H), 7.83-7.91 (m, 3H), 8.50-8.56 (m, 1H); MS (DCI/NH3) m/z 340 (M+H)+; Anal. C19H21N3OS.HCl.0.5H2O: C, H, N.

Sources & evidence

ORD record
ord-826157a0d8f2413abbf8669c977d5a83
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

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