Ammonia → HCID 67152145, compound

Participants

Reaction Steps

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 5-(2-pyridyl)thiophene-2-carboxylic acid (Maybridge) according to methods A and C; yield 49 mg, 0.14 mmol (66%): 1H NMR (300 MHz, methanol-d4) δ 1.98 (d, J=14 Hz, 2H), 2.21 (s, 1H), 2.34 (d, J=14 Hz, 2H), 2.50 (s, 2H), 3.58 (s, 2H), 3.68 (s, 4H), 4.41 (s, 1H), 7.75 (dt, J=7, 6, 1 Hz, 1H), 7.92 (d, J=4 Hz, 1H), 8.00 (d, J=4 Hz, 1H), 8.21 (d, J=8 Hz, 1H), 8.34 (dt, J=8, 2 Hz, 1H), 8.69 (d, J=5 Hz, 1H); MS (DCI/NH3) m/z 340 (M+H)+; Anal. C21H21F3N2O2.2HCl.0.2H2O.0.1C4H8O2: C, H, N.

Provenance & Evidence