Ammonia → HCID 67274204, compound

HRID 599222Notes

Reaction equation

HRID 599222 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[C:18]1[S:19][CH:20]=[C:21]([C:23](O)=[O:24])[N:22]=1.N>>[ClH:1].[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:23]([C:21]3[N:22]=[C:18]([C:14]4[S:13][CH:17]=[CH:16][CH:15]=4)[S:19][CH:20]=3)=[O:24])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 27763172-(Thiophen-2-yl)-1,3-thiazole-4-carboxylic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67274204HCID 67274204, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 2-(2-thienyl)-1,3-thiazole-4-carboxylic acid (Maybridge) according to methods A and C; yield 103 mg, 0.25 mmol (62%): 1H NMR (300 MHz, methanol-d4) δ 2.04-2.32 (m, 3H), 2.51 (s, 2H), 2.51 (s, 2H), 3.46-3.62 (m, 4H), 3.82 (d, J=13 Hz, 2H), 4.29 (s, 1H), 7.18 (dd, J=5, 4 Hz, 1H), 7.65 (dd, J=5, 1 Hz, 1H), 7.64 (dd, J=5, 1 Hz, 1H), 7.72 (dd, J=4, 1 Hz, 1H), 8.21 (s, 1H); MS (DCI/NH3) m/z 346 (M+H)+; Anal. C17H19N3OS2.2HCl: C, H, N.

Sources & evidence

ORD record
ord-87dcaef3c5694c1882c9a6be896a07ba
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

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