Ammonia → HCID 16067941, compound

HRID 599229Notes

Reaction equation

HRID 599229 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[Cl:12][C:13]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](O)=[O:16].N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:15](=[O:16])[C:14]3[CH:18]=[CH:19][CH:20]=[C:21]([Cl:22])[C:13]=3[Cl:12])[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 57652,3-Dichlorobenzoic acidHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 16067941HCID 16067941, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 2,3-dichlorobenzoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.91-1.99 (m, 6H), 2.07 (d, 1H), 2.26 (d, J=13 Hz, 2H), 2.35 (s, 2H), 3.44-3.52 (m, 2H), 3.77-3.89 (m, 1H), 4.43 (s, 1H), 7.36-7.42 (m, 2H), 7.63 (dd, J=6, 4 Hz, 1H); MS (APCI/NH3) m/z 325 (M+H)+.

Sources & evidence

ORD record
ord-3ce55b2b15794870b1d8704af5cc5383
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

Loading…