4-Hydroxybenzoic Acid → HCID 67152127, compound

HRID 599233Notes

Reaction equation

HRID 599233 reaction equation
[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH2:11])[CH2:2]1)[CH2:8]2.[OH:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=1.N>>[N:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([C@@H:4]3[NH:11][C:17](=[O:18])[C:16]3[CH:20]=[CH:21][C:13]([OH:12])=[CH:14][CH:15]=3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 3

HCID 1354-Hydroxybenzoic AcidHCID 222AmmoniaHCID 156866181-Azatricyclo[3.3.1.1,3,7]decan-4-amine

Product 1

HCID 67152127HCID 67152127, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 4-hydroxybenzoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.91-1.98 (m, 5H), 2.14 (s, 1H), 2.27-2.34 (m, 2H), 2.36-2.43 (m, 1H), 3.50 (s, 2H), 3.60 (s, 3H), 4.36 (s, 1H), 6.70-6.98 (m, 2H), 7.56-7.82 (m, 2H); MS (APCI/NH3) m/z 273 (M+H)+.

Sources & evidence

ORD record
ord-6940eb2013e745c9b2b0089abea59a4d
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

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