Ammonia → N-[(4s)-1-Azatricyclo[3.3.1.13,7]dec-4-yl]-4-phenoxybenzamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	4-Phenoxybenzoic acid	HCID 75182	—
Reactant	1-Azatricyclo[3.3.1.1,3,7]decan-4-amine	HCID 15686618	—
Product	N-[(4s)-1-Azatricyclo[3.3.1.13,7]dec-4-yl]-4-phenoxybenzamide	HCID 16068053	—

Reaction Steps

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine and 4-phenoxybenzoic acid (Aldrich) according to method B; 1H NMR (500 MHz, methanol-d4) δ 1.95 (d, J=13 Hz, 2H), 2.11 (s, 1H), 2.31 (d, J=13 Hz, 2H), 2.38 (s, 2H), 3.49 (s, 2H), 3.59 (s, 4H), 4.38 (s, 1H), 7.00-7.09 (m, 4H), 7.17-7.23 (m, 1H), 7.38-7.44 (m, J=8, 8 Hz, 2H), 7.81-7.89 (m, 2H); MS (APCI/NH3) m/z 349 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07897766B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-107ca2a23ef24a8dba551d095d9e7fe5
Source note	uspto-grants-2011_03