HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 67152133, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1,4-Benzodioxane-6-carboxylic Acid | HCID 2758833 | — |
| Reactant | 1-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride | HCID 67152122 | — |
| Product | HCID 67152133 | HCID 67152133 | — |
Reaction Steps
Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 1,4-benzodioxan-6-carboxylic acid (Maybridge) according to methods A and C; yield 49 mg, 0.14 mmol (43%): 1H NMR (300 MHz, methanol-d4) δ 1.94 (d, J=13 Hz, 2H), 2.18 (s, 2H), 2.30 (d, J=14 Hz, 2H), 2.44 (s, 2H), 3.55 (s, 1H), 3.65 (d, J=2 Hz, 4H), 4.24-4.32 (m, 4H), 4.35 (s, 1H), 6.90 (ddd, J=9, 1 Hz, 1H), 7.33-7.39 (m, 2H); MS (DCI/NH3) m/z 315 (M+H)+; Anal. C18H22N2O3.HCl.0.25H2O: C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897766B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-645ef6f4d19a4208a323f7c1aa78ddac |
| Source note | uspto-grants-2011_03 |