Ammonia → HCID 67152173, compound

HRID 599246Notes

Reaction equation

HRID 599246 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[C:23](O)=[O:24].N>>[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:23]([C:14]3[CH:15]=[CH:16][C:17]4[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=4)[CH:13]=3)=[O:24])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 71232-Naphthoic acidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152173HCID 67152173, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 2-naphthoic acid according to methods A and C. 1H NMR (300 MHz, methanol-d4) δ ppm 2.08-2.34 (m, 5H), 2.51 (s, 2H), 3.42-3.64 (m, 4H), 3.88 (d, J=12.5 Hz, 2H), 4.33 (s, 1H), 7.51-7.67 (m, 2H), 7.85-8.07 (m, 4H), 8.46 (s, 1H). MS (DCI/NH3) m/z 308. Anal. Calculated for C20H22N2O.HCl: C, 70.06; H, 6.76; N, 9.14. Found: C, 69.72; H, 6.58; N, 8.03.

Sources & evidence

ORD record
ord-5fba54b4bfdd4f009e5636914b4e551e
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

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