反应详情

To a stirring solution of amine (2 mmol, 1.00 eq) and pyridine (4 mmol, 2.00 eq) in CH2Cl2 (18 ml) at RT was added Troc-Cl (1.87 mmol, 1.05 eq). After 4 hours the reaction was washed with 3M HCl (1×), satd. NaHCO3 (1×), dried (Na2SO4), filtered and evaporated to afford the target 2,2,2-trichloroethyl carbamate. The material was used as is in the next reaction.

1. washAfter 4 hours the reaction was washed with 3M HCl (1×)
2. dry with materialNaHCO3 (1×), dried (Na2SO4)
3. filtrationfiltered
4. customevaporated