Triethylamine → HCID 86629438, compound

Participants

Reaction Steps

Using the procedure of Example A4 step 3, diphosgene (1.3 g, 6.4 mmol), 5-((4-fluoro-2-methyl-5-nitrophenylamino)methyl)-N4-isopropyl-N2-methoxy-N2-methylpyridine-2,4-diamine (2.0 g, 5.3 mmol) and Et3N (2.2 g, 21.2 mmol) were reacted in dioxane to give 3-(4-fluoro-2-methyl-5-nitrophenyl)-1-isopropyl-7-(methoxy(methyl)amino)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one (1.5 g, 70% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.18 (d, J=7.2 Hz, 1 H), 7.94 (s, 1 H), 7.55 (d, J=12.4 Hz, 1 H), 6.68 (s, 1 H), 4.77 (d, J=13.6 Hz, 1 H), 4.45-4.37 (m, 2 H), 3.71 (s, 3 H), 3.13 (s, 3 H), 2.14 (s, 3 H), 1.46 (t, J=6.4 Hz, 6H).

Provenance & Evidence