HCID 86629449, compound → HCID 67063112, compound

Participants

Reaction Steps

1-Ethyl-3-(4-fluoro-3-nitrophenyl)-7-(methoxy(methyl)amino)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one (4.6 g, 12 mmol), Pd/C (0.5 g) and hydrogen (45 psi) were reacted in MeOH (100 mL) at 50° C. overnight to give 3-(3-amino-4-fluorophenyl)-1-ethyl-7-(methylamino)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one (3.2 g, 84%). 1H-NMR (400 MHz, DMSO-d6): δ 7.70 (s, 1 H), 6.94 (dd, J=11.2, 8.8 Hz, 1 H), 6.67 (dd, J=8.0, 2.4 Hz, 1 H), 6.42 (m, 1 H), 6.33 (m, 1 H), 5.98 (s, 1 H), 5.14 (s, 2 H), 4.48 (s, 2 H), 3.74 (q, J=7.2 Hz, 2 H), 2.73 (d, J=5.2 Hz, 3 H), 1.15 (t, J=7.2 Hz, 3 H); MS (ESI) m/z: 316.2 [M+H]+.

Provenance & Evidence