HCID 86629451, compound → HCID 86629452, compound

Participants

Reaction Steps

A mixture of (4-tert-butylamino-6-chloro-pyridin-3-yl)-methanol (5.0 g, 23.4 mmol) and MnO2 (14.3 g, 163.6 mmol) in anhydrous CH2Cl2 (100 mL) was stirred at RT for 10 h. The reaction was filtered and the filtrate was concentrated to give 4-(tert-butylamino)-6-chloronicotinaldehyde (4.0 g, 87.0% yield), which was used in the next step without further purification. 1H NMR (400 MHz, DMSO-d6): δ 9.83 (s, 1 H), 8.90 (s, 1 H), 8.44 (s, 1 H), 6.86 (s, 1 H), 1.40 (s, 9 H).

Provenance & Evidence