HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-Azabicyclo[3.2.1]oct-2-ene-3-yl trifluoromethylsulfonate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 8-Boc-3-(trifluoromethylsulfonyloxy)-8-azabicyclo[3.2.1]oct-3-ene | HCID 22648094 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-Azabicyclo[3.2.1]oct-2-ene-3-yl trifluoromethylsulfonate hydrochloride | HCID 86632180 | — |
Reaction Steps
2.76 g of tert-butyl 3-{[(trifluoromethyl)sulfonyl]oxy}-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate in 13 ml of dioxane are placed in a 100 ml round-bottomed flask. 12.8 ml of a 4N solution of hydrochloric acid in dioxane are then carefully added. The reaction mixture is stirred for 3 h. The dioxane is evaporated off, to give 2.27 g of 8-azabicyclo[3.2.1]oct-2-ene-3-yl trifluoromethylsulfonate hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897773B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-7292038c52d94cd386c1f95fc3910ba1 |
| Source note | uspto-grants-2011_03 |