Tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate → Tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate

Participants

Reaction Steps

In a high-pressure reactor, under nitrogen, 0.17 g of 5% palladium-on-charcoal is added to 0.46 g of tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate solubilized in 20 ml of methanol. The reaction mixture is placed under a hydrogen pressure of 3 atmospheres at 25° C., and mechanically stirred for two and a half hours. The palladium is filtered off on Whatman paper and washed with methanol. The solvent is evaporated off and 0.46 g of tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate is obtained.

Provenance & Evidence