Water → HCID 178522063, compound

Participants

Reaction Steps

O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetrauroniumhexafluorophosphate (5.4 g, 14 mmol) was added to a suspension of 2-mercaptonicotinic acid (2.0 g, 13 mmol), 4-chloroaniline (1.7 g, 13 mmol) and N,N-diisopropylethylamine (4.5 mL, 26 mmol) in anhydrous N,N-dimethylformamide (20 mL) at room temperature, and the mixture was stirred for 20 hours. Water (20 mL) was added thereto, the precipitated solid was filtered off, and washed with ethyl acetate. The resulting solid was dried at 40° C. under reduced pressure to give 2.0 g of the title Reference Compound as a yellow solid (Yield: 59%)

Provenance & Evidence