2-{1-[2-(2-chloro-ethoxy)-ethyl]-2,6-dimethyl-1H-pyridin-4-ylidene}-malononitrile → HCID 86616549, compound

Participants

Reaction Steps

A 50 ml reaction flask, equipped with a reflux condenser, a heating bath and a magnetic stirrer was charged under Argon with 1.4 g (5 mmol) of the above 2-{1-[2-(2-chloro-ethoxy)-ethyl]-2,6-dimethyl-1H-pyridin-4-ylidene}-malononitrile in 25 ml of pyridine and heated to reflux for 5 hours. A heavy suspension was formed, which was filtered off and washed with a small amount of cold pyridine followed by THF. After drying 1.69 g of fine crystals were obtained, m.p. 248-251° C./decomp. UV (water) 352 nm (E=1149). Solubility in water>>200 g/l.

Provenance & Evidence