Acetone → HCID 131728724, compound

HRID 599399Notes

Reaction equation

HRID 599399 reaction equation
[CH3:1][C:2]([CH3:4])=O.[C:5]([O:9][C:10](=[O:32])[NH:11][CH2:12][CH2:13][CH2:14][N:15]1[C:27]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[N:20]=[C:19]([NH2:28])[C:18]=2[N:17]=[C:16]1[CH2:29][O:30][NH2:31])([CH3:8])([CH3:7])[CH3:6]>CO>[C:5]([O:9][C:10](=[O:32])[NH:11][CH2:12][CH2:13][CH2:14][N:15]1[C:27]2[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[N:20]=[C:19]([NH2:28])[C:18]=2[N:17]=[C:16]1[CH2:29][O:30][N:31]=[C:2]([CH3:4])[CH3:1])([CH3:8])([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 180AcetoneHCID 86627649HCID 86627649, compound

Product 1

HCID 131728724HCID 131728724, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetone (20 mL) was added to a solution of tert-butyl[3-(4-amino-2-aminooxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]carbamate (3.6 g) in methanol (70 mL). The reaction mixture was stirred at ambient temperature overnight and then concentrated under reduced pressure to provide 4.12 g of tert-butyl[3-(4-amino-2-isopropylideneaminoxymethyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]carbamate as a light yellow foam.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9f010147111b4dfa9e20a28322c074bd
Source dataset
uspto-grants-2011_03
Patent number
US07897767B2

Reaction notes

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