Chloroacetyl chloride → HCID 66958132, compound

Participants

Reaction Steps

Chloroacetyl chloride (5.00 mL, 63.4 mmol) was added dropwise to a 0° C. solution of tert-butyl 3-[(3-amino[1,5]naphthyridin-4-yl)amino]propylcarbamate (from Part B, approximately 57.6 mmol) in dichloromethane (230 mL). The reaction was allowed to warm to room temperature and was stirred for 1 hour. The solvent was removed under reduced pressure to afford tert-butyl 3-({3-[(chloroacetyl)amino]-[1,5]naphthyridin-4-yl}amino)propylcarbamate hydrochloride as a solid, all of which was used in the next step.

Provenance & Evidence